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Drug class

Antitussives (Opioid Antitussives and DM)

The phrase "Antitussives (Opioid Antitussives and DM)" represents a combined functional category rather than a single standardized pharmacological class, grouping centrally acting opioid suppressants—principally codeine and hydrocodone—with dextromethorphan (DM), a synthetic morphinan derivative. Read more about Antitussives (Opioid Antitussives and DM)

1,151 drugs in this class 155 manufacturers

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Drugs in Antitussives (Opioid Antitussives and DM)

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About Antitussives (Opioid Antitussives and DM).

The phrase "Antitussives (Opioid Antitussives and DM)" represents a combined functional category rather than a single standardized pharmacological class, grouping centrally acting opioid suppressants—principally codeine and hydrocodone—with dextromethorphan (DM), a synthetic morphinan derivative.

These agents act primarily within the central nervous system to elevate the cough reflex threshold in the brainstem, with opioids stimulating central mu-opioid receptors and dextromethorphan exerting non-opioid antitussive effects largely via sigma-1 receptor agonism and NMDA receptor antagonism.

Clinically, medications in this grouping are indicated for the short-term, symptomatic suppression of nonproductive cough associated with acute upper respiratory tract infections, allergies, and bronchitis.