Drug class

Antiviral-HIV Boosted Protease Inhibitors

Antiviral HIV boosted protease inhibitors are an antiretroviral regimen category rather than an isolated chemical subclass, consisting of an HIV-1 protease inhibitor co-administered with a pharmacokinetic enhancing agent such as low-dose ritonavir or cobicistat. Read more about Antiviral-HIV Boosted Protease Inhibitors

29 drugs in this class 18 manufacturers

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Drugs in Antiviral-HIV Boosted Protease Inhibitors

Showing 1–9 of 29 drugs

APTIVUS (tipranavir)

ANTIVIRAL-HIV (ANTIRETROVIRAL) PROTEASE INHIBITORS · HIV INFECTION
Boehringer Ingelheim

PREZISTA (darunavir)

ANTIVIRAL-HIV (ANTIRETROVIRAL) PROTEASE INHIBITORS · HIV INFECTION
JANSSEN PRODUCT

PREZISTA (darunavir)

ANTIVIRAL-HIV (ANTIRETROVIRAL) PROTEASE INHIBITORS · HIV INFECTION
JANSSEN PRODUCT
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About Antiviral-HIV Boosted Protease Inhibitors.

Antiviral HIV boosted protease inhibitors are an antiretroviral regimen category rather than an isolated chemical subclass, consisting of an HIV-1 protease inhibitor co-administered with a pharmacokinetic enhancing agent such as low-dose ritonavir or cobicistat.

The pharmacokinetic booster selectively inhibits cytochrome P450 3A4 enzymes, significantly elevating and prolonging circulating levels of the primary protease inhibitor to prevent the cleavage of viral Gag and Gag-Pol polyproteins into mature, infectious virions.

Characterized by a high genetic barrier to resistance, these boosted combinations are primarily utilized alongside nucleoside reverse transcriptase inhibitors for the management and treatment of HIV-1 infection in treatment-naive individuals and patients with prior antiretroviral exposure or suspected resistance.