Antiviral-HIV Cytidine Analogue Nucleoside RT Inhibitors

Antiviral-HIV cytidine analogue nucleoside reverse transcriptase inhibitors (NRTIs) are a structural subcategory of antiretroviral agents, most prominently represented by lamivudine and emtricitabine

Antiviral-HIV cytidine analogue nucleoside reverse transcriptase inhibitors (NRTIs) are a structural subcategory of antiretroviral agents, most prominently represented by lamivudine and emtricitabine

These agents mimic the endogenous pyrimidine nucleoside cytidine and, following intracellular phosphorylation into active triphosphate metabolites, compete with deoxycytidine triphosphate for incorporation into nascent viral DNA by HIV reverse transcriptase They serve as foundational backbone components in combination antiretroviral therapy for the management and prevention of human immunodeficiency virus type 1 (HIV-1) infection, and frequently possess concurrent therapeutic activity against he...

These agents mimic the endogenous pyrimidine nucleoside cytidine and, following intracellular phosphorylation into active triphosphate metabolites, compete with deoxycytidine triphosphate for incorporation into nascent viral DNA by HIV reverse transcriptase

Because they lack a 3′-hydroxyl group, their incorporation causes premature viral DNA chain termination and prevents replication

Because they lack a 3′-hydroxyl group, their incorporation causes premature viral DNA chain termination and prevents replication

They serve as foundational backbone components in combination antiretroviral therapy for the management and prevention of human immunodeficiency virus type 1 (HIV-1) infection, and frequently possess concurrent therapeutic activity against hepatitis B virus (HBV) infection