Biguanides

Biguanides are a pharmacologic class of oral antihyperglycemic agents primarily indicated for the management of type 2 diabetes mellitus

Biguanides are a pharmacologic class of oral antihyperglycemic agents primarily indicated for the management of type 2 diabetes mellitus

They exert their therapeutic effects predominantly by reducing endogenous hepatic glucose production, decreasing intestinal glucose absorption, and enhancing peripheral insulin sensitivity to improve glucose uptake and utilization Metformin is the predominant agent of this class in modern clinical practice, serving as a foundational first-line therapy to improve glycemic control without stimulating insulin secretion or causing significant hypoglycemia

They exert their therapeutic effects predominantly by reducing endogenous hepatic glucose production, decreasing intestinal glucose absorption, and enhancing peripheral insulin sensitivity to improve glucose uptake and utilization

Metformin is the predominant agent of this class in modern clinical practice, serving as a foundational first-line therapy to improve glycemic control without stimulating insulin secretion or causing significant hypoglycemia