Bile Sequestrants

Bile sequestrants, more formally termed bile acid sequestrants or bile acid resins, are a therapeutic class of nonabsorbable, positively charged polymeric agents They exert their principal effect by binding negatively charged bile acids in the gastrointestinal tract to form insoluble complexes that are eliminated in the feces, thereby interrupting enterohepatic recirculation

They exert their principal effect by binding negatively charged bile acids in the gastrointestinal tract to form insoluble complexes that are eliminated in the feces, thereby interrupting enterohepatic recirculation This depletion prompts the liver to convert endogenous cholesterol into new bile acids and upregulate hepatic low-density lipoprotein receptors, which lowers circulating low-density lipoprotein cholesterol Clinically, these agents are used primarily to treat hypercholesterolemia, imp...

This depletion prompts the liver to convert endogenous cholesterol into new bile acids and upregulate hepatic low-density lipoprotein receptors, which lowers circulating low-density lipoprotein cholesterol

Clinically, these agents are used primarily to treat hypercholesterolemia, improve glycemic control in type 2 diabetes mellitus, and manage chronic diarrhea caused by bile acid malabsorption

Clinically, these agents are used primarily to treat hypercholesterolemia, improve glycemic control in type 2 diabetes mellitus, and manage chronic diarrhea caused by bile acid malabsorption