Dopamine-Depleting Agents

Dopamine-depleting agents are a class of medications that decrease presynaptic dopamine concentrations and suppress monoaminergic neurotransmission in the central nervous system

Dopamine-depleting agents are a class of medications that decrease presynaptic dopamine concentrations and suppress monoaminergic neurotransmission in the central nervous system They achieve this principally by inhibiting vesicular monoamine transporter 2 (VMAT2), which blocks the packaging of dopamine into presynaptic vesicles and promotes its metabolic degradation Clinically, these agents are primarily indicated for hyperkinetic movement disorders, most notably chorea associated with Huntingto...

Dopamine-depleting agents are a class of medications that decrease presynaptic dopamine concentrations and suppress monoaminergic neurotransmission in the central nervous system They achieve this principally by inhibiting vesicular monoamine transporter 2 (VMAT2), which blocks the packaging of dopamine into presynaptic vesicles and promotes its metabolic degradation

They achieve this principally by inhibiting vesicular monoamine transporter 2 (VMAT2), which blocks the packaging of dopamine into presynaptic vesicles and promotes its metabolic degradation Clinically, these agents are primarily indicated for hyperkinetic movement disorders, most notably chorea associated with Huntington’s disease, tardive dyskinesia, and tic disorders

Representative agents in this pharmacological category include tetrabenazine, deutetrabenazine, and reserpine

Representative agents in this pharmacological category include tetrabenazine, deutetrabenazine, and reserpine

Clinically, these agents are primarily indicated for hyperkinetic movement disorders, most notably chorea associated with Huntington’s disease, tardive dyskinesia, and tic disorders