Fibric Acid Derivatives

Fibric acid derivatives, commonly referred to as fibrates, are a class of lipid-lowering medications that include agents such as gemfibrozil and fenofibrate Clinically, these agents are primarily indicated as adjuncts to diet for the treatment of severe hypertriglyceridemia—often to reduce the risk of acute pancreatitis—and are also utilized in the management of mixed dyslipidemia and primary hypercholesterolemia

Fibric acid derivatives, commonly referred to as fibrates, are a class of lipid-lowering medications that include agents such as gemfibrozil and fenofibrate

They function primarily as agonists of the nuclear receptor peroxisome proliferator-activated receptor alpha (PPAR-alpha), which alters the transcription of genes regulating lipoprotein metabolism, enhances lipoprotein lipase activity, stimulates cellular fatty acid beta-oxidation, and substantially decreases circulating plasma triglycerides while modestly increasing high-density lipoprotein cholesterol Clinically, these agents are primarily indicated as adjuncts to diet for the treatment of sev...

They function primarily as agonists of the nuclear receptor peroxisome proliferator-activated receptor alpha (PPAR-alpha), which alters the transcription of genes regulating lipoprotein metabolism, enhances lipoprotein lipase activity, stimulates cellular fatty acid beta-oxidation, and substantially decreases circulating plasma triglycerides while modestly increasing high-density lipoprotein cholesterol