PEMFEXY (pemetrexed)
FOLATE ANTAGONISTS · MALIGNANT MESOTHELIOMA OF PLEURA ·+2
ACACIA PHARMA
Drug class
Folate Antagonists
Folate antagonists, also known as antifolates, are an antimetabolite drug class that structurally mimics folic acid and interferes with folate-dependent cellular metabolism. Read more about Folate Antagonists
66 drugs in this class 51 manufacturers
Drugs in Folate Antagonists
METHOTREXATE (methotrexate sodium/PF)
ANTIPSORIATICS · OSTEOSARCOMA OF BONE ·+12
Hikma Pharmaceuticals USA
METHOTREXATE (methotrexate sodium)
ANTIPSORIATICS · MYCOSIS FUNGOIDES ·+5
AHP
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Folate antagonists, also known as antifolates, are an antimetabolite drug class that structurally mimics folic acid and interferes with folate-dependent cellular metabolism.
They act primarily by competitively inhibiting key enzymes such as dihydrofolate reductase (DHFR) and thymidylate synthase, thereby blocking the synthesis of tetrahydrofolate cofactors necessary for de novo purine and pyrimidine nucleotide production and cellular replication.
Because rapidly dividing cells are uniquely susceptible to this disruption in DNA and RNA synthesis, folate antagonists are widely utilized in oncology for hematologic malignancies and solid tumors, in rheumatology for inflammatory conditions such as rheumatoid arthritis, and in infectious diseases to treat or prevent parasitic and bacterial infections.
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cancer.gov
Folate antagonists, also known as antifolates, are an antimetabolite drug class that structurally mimics folic acid and interferes with folate-dependent cellular metabolism Because rapidly dividing cells are uniquely susceptible to this disruption in DNA and RNA synthesis, folate antagonists are widely utilized in oncology for hematologic malignancies and solid tumors, in rheumatology for inflammatory conditions such as rheumatoid arthritis, and in infectious diseases to treat or prevent parasit...
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nih.gov
Folate antagonists, also known as antifolates, are an antimetabolite drug class that structurally mimics folic acid and interferes with folate-dependent cellular metabolism They act primarily by competitively inhibiting key enzymes such as dihydrofolate reductase (DHFR) and thymidylate synthase, thereby blocking the synthesis of tetrahydrofolate cofactors necessary for de novo purine and pyrimidine nucleotide production and cellular replication
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fda.gov
They act primarily by competitively inhibiting key enzymes such as dihydrofolate reductase (DHFR) and thymidylate synthase, thereby blocking the synthesis of tetrahydrofolate cofactors necessary for de novo purine and pyrimidine nucleotide production and cellular replication
-
nih.gov
They act primarily by competitively inhibiting key enzymes such as dihydrofolate reductase (DHFR) and thymidylate synthase, thereby blocking the synthesis of tetrahydrofolate cofactors necessary for de novo purine and pyrimidine nucleotide production and cellular replication Because rapidly dividing cells are uniquely susceptible to this disruption in DNA and RNA synthesis, folate antagonists are widely utilized in oncology for hematologic malignancies and solid tumors, in rheumatology for infla...
-
nih.gov
Because rapidly dividing cells are uniquely susceptible to this disruption in DNA and RNA synthesis, folate antagonists are widely utilized in oncology for hematologic malignancies and solid tumors, in rheumatology for inflammatory conditions such as rheumatoid arthritis, and in infectious diseases to treat or prevent parasitic and bacterial infections
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