Leukocyte Stimulating Factors

"Leukocyte Stimulating Factors" is an administrative and compendial drug classification—more formally recognized by standard compendia and regulatory bodies as colony-stimulating factors or hematopoietic growth factors These biologic agents act primarily by binding to specific cell-surface receptors on hematopoietic progenitor cells in the bone marrow, stimulating the proliferation, differentiation, and activation of white blood cells such as neutrophils and monocytes Clinically, they are used t...

These biologic agents act primarily by binding to specific cell-surface receptors on hematopoietic progenitor cells in the bone marrow, stimulating the proliferation, differentiation, and activation of white blood cells such as neutrophils and monocytes Clinically, they are used to prevent and manage severe neutropenia, reduce the risk of life-threatening infections following myelosuppressive chemotherapy or bone marrow transplantation, and treat hematopoietic acute radiation syndrome