MELPHALAN HCL
NITROGEN MUSTARD DERIVATIVES · MULTIPLE MYELOMA
DR.REDDY'S LAB
Drug class
Nitrogen Mustard Derivatives
Nitrogen mustard derivatives are a foundational class of cytotoxic alkylating antineoplastic agents structurally derived from bis-(2-chloroethyl)amines. Read more about Nitrogen Mustard Derivatives
62 drugs in this class 45 manufacturers
Drugs in Nitrogen Mustard Derivatives
CYCLOPHOSPHAMIDE
NITROGEN MUSTARD DERIVATIVES · RETINOBLASTOMA ·+17
AMERIGEN PHARMA
CYCLOPHOSPHAMIDE
NITROGEN MUSTARD DERIVATIVES · RETINOBLASTOMA ·+17
STI PHARMA, LLC
MELPHALAN HCL
NITROGEN MUSTARD DERIVATIVES · MULTIPLE MYELOMA
FRESENIUS KABI
CYCLOPHOSPHAMIDE
NITROGEN MUSTARD DERIVATIVES · RETINOBLASTOMA ·+17
NORTHSTAR RX LL
CYCLOPHOSPHAMIDE
NITROGEN MUSTARD DERIVATIVES · RETINOBLASTOMA ·+17
BLUEPOINT LABOR
CYCLOPHOSPHAMIDE
NITROGEN MUSTARD DERIVATIVES · RETINOBLASTOMA ·+17
AMNEAL BIOSCIEN
CYCLOPHOSPHAMIDE
NITROGEN MUSTARD DERIVATIVES · RETINOBLASTOMA ·+17
CIPLA USA, INC.
CYCLOPHOSPHAMIDE
NITROGEN MUSTARD DERIVATIVES · RETINOBLASTOMA ·+17
Hikma Pharmaceuticals USA
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Nitrogen mustard derivatives are a foundational class of cytotoxic alkylating antineoplastic agents structurally derived from bis-(2-chloroethyl)amines.
They exert their principal therapeutic effect by forming reactive aziridinium intermediates that covalently bind to DNA bases—chiefly guanine residues—producing intra- and inter-strand cross-links that disrupt replication and transcription, ultimately triggering apoptotic cell death in rapidly dividing cells.
Clinically represented by agents such as cyclophosphamide, chlorambucil, melphalan, ifosfamide, and bendamustine, this class is widely employed in oncology and hematology to treat leukemias, lymphomas, multiple myeloma, and various solid tumors, as well as serving key immunosuppressive roles in conditioning regimens for stem cell transplantation and severe autoimmune disorders.
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drugbank.com
Nitrogen mustard derivatives are a foundational class of cytotoxic alkylating antineoplastic agents structurally derived from bis-(2-chloroethyl)amines
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nih.gov
Nitrogen mustard derivatives are a foundational class of cytotoxic alkylating antineoplastic agents structurally derived from bis-(2-chloroethyl)amines They exert their principal therapeutic effect by forming reactive aziridinium intermediates that covalently bind to DNA bases—chiefly guanine residues—producing intra- and inter-strand cross-links that disrupt replication and transcription, ultimately triggering apoptotic cell death in rapidly dividing cells Clinically represented by agents such ...
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uni-regensburg.de
They exert their principal therapeutic effect by forming reactive aziridinium intermediates that covalently bind to DNA bases—chiefly guanine residues—producing intra- and inter-strand cross-links that disrupt replication and transcription, ultimately triggering apoptotic cell death in rapidly dividing cells
-
nih.gov
They exert their principal therapeutic effect by forming reactive aziridinium intermediates that covalently bind to DNA bases—chiefly guanine residues—producing intra- and inter-strand cross-links that disrupt replication and transcription, ultimately triggering apoptotic cell death in rapidly dividing cells
-
nih.gov
Clinically represented by agents such as cyclophosphamide, chlorambucil, melphalan, ifosfamide, and bendamustine, this class is widely employed in oncology and hematology to treat leukemias, lymphomas, multiple myeloma, and various solid tumors, as well as serving key immunosuppressive roles in conditioning regimens for stem cell transplantation and severe autoimmune disorders
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