Drug class
Nitrosoureas
Nitrosoureas are a distinct class of lipophilic alkylating antineoplastic agents that exert cytotoxic effects by alkylating and cross-linking DNA, thereby inhibiting nucleic acid synthesis and cell division. Read more about Nitrosoureas
18 drugs in this class 16 manufacturers
Drugs in Nitrosoureas
GLEOSTINE (lomustine)
CARMUSTINE
CARMUSTINE
CARMUSTINE
BICNU (carmustine)
GLIADEL WAFER (carmustine in polifeprosan 20)
CARMUSTINE
CARMUSTINE
Nitrosoureas are a distinct class of lipophilic alkylating antineoplastic agents that exert cytotoxic effects by alkylating and cross-linking DNA, thereby inhibiting nucleic acid synthesis and cell division.
Due to their marked lipid solubility, agents such as carmustine and lomustine readily cross the blood-brain barrier, making them clinically important therapies for central nervous system malignancies, including high-grade gliomas and brain metastases.
They are also utilized, often in combination regimens, to treat lymphomas, multiple myeloma, and, in the case of streptozocin, pancreatic neuroendocrine islet cell tumors.
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nih.gov
Nitrosoureas are a distinct class of lipophilic alkylating antineoplastic agents that exert cytotoxic effects by alkylating and cross-linking DNA, thereby inhibiting nucleic acid synthesis and cell division They are also utilized, often in combination regimens, to treat lymphomas, multiple myeloma, and, in the case of streptozocin, pancreatic neuroendocrine islet cell tumors
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nih.gov
Nitrosoureas are a distinct class of lipophilic alkylating antineoplastic agents that exert cytotoxic effects by alkylating and cross-linking DNA, thereby inhibiting nucleic acid synthesis and cell division Due to their marked lipid solubility, agents such as carmustine and lomustine readily cross the blood-brain barrier, making them clinically important therapies for central nervous system malignancies, including high-grade gliomas and brain metastases They are also utilized, often in combinati...
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picmonic.com
Nitrosoureas are a distinct class of lipophilic alkylating antineoplastic agents that exert cytotoxic effects by alkylating and cross-linking DNA, thereby inhibiting nucleic acid synthesis and cell division Due to their marked lipid solubility, agents such as carmustine and lomustine readily cross the blood-brain barrier, making them clinically important therapies for central nervous system malignancies, including high-grade gliomas and brain metastases They are also utilized, often in combinati...
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cancer.gov
Due to their marked lipid solubility, agents such as carmustine and lomustine readily cross the blood-brain barrier, making them clinically important therapies for central nervous system malignancies, including high-grade gliomas and brain metastases
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