Oral Antivirals for Chronic Hepatitis B

Oral antivirals for chronic hepatitis B primarily consist of nucleoside and nucleotide analogues, including agents such as entecavir, tenofovir disoproxil fumarate, and tenofovir alafenamide

Oral antivirals for chronic hepatitis B primarily consist of nucleoside and nucleotide analogues, including agents such as entecavir, tenofovir disoproxil fumarate, and tenofovir alafenamide Clinically, they are used to manage chronic hepatitis B virus infection to achieve long-term viral suppression, normalize liver enzymes, reduce hepatic inflammation, and lower the risks of progressive fibrosis, cirrhosis, end-stage liver failure, and hepatocellular carcinoma

These agents function by selectively inhibiting the reverse transcriptase and DNA polymerase activities of the hepatitis B virus, thereby causing viral DNA chain termination and suppressing replication Clinically, they are used to manage chronic hepatitis B virus infection to achieve long-term viral suppression, normalize liver enzymes, reduce hepatic inflammation, and lower the risks of progressive fibrosis, cirrhosis, end-stage liver failure, and hepatocellular carcinoma

These agents function by selectively inhibiting the reverse transcriptase and DNA polymerase activities of the hepatitis B virus, thereby causing viral DNA chain termination and suppressing replication