Polymyxins

Polymyxins are a class of cyclic polypeptide antibiotics, principally represented in clinical use by polymyxin B and colistin (polymyxin E)

Polymyxins are a class of cyclic polypeptide antibiotics, principally represented in clinical use by polymyxin B and colistin (polymyxin E)

They exert bactericidal activity by binding directly to the lipopolysaccharide and phospholipids of the bacterial outer membrane, disrupting membrane integrity and causing leakage of intracellular contents

They exert bactericidal activity by binding directly to the lipopolysaccharide and phospholipids of the bacterial outer membrane, disrupting membrane integrity and causing leakage of intracellular contents Systemic administration is typically reserved for hospitalized patients with life-threatening infections, such as hospital-acquired pneumonia, bacteremia, and complicated urinary tract infections, where other antimicrobial options are ineffective or contraindicated

Due to their efficacy against challenging pathogens, polymyxins serve as critical reserve agents for severe, multidrug-resistant Gram-negative infections, notably those involving *Pseudomonas aeruginosa*, *Acinetobacter baumannii*, and carbapenem-resistant Enterobacterales

Due to their efficacy against challenging pathogens, polymyxins serve as critical reserve agents for severe, multidrug-resistant Gram-negative infections, notably those involving *Pseudomonas aeruginosa*, *Acinetobacter baumannii*, and carbapenem-resistant Enterobacterales Systemic administration is typically reserved for hospitalized patients with life-threatening infections, such as hospital-acquired pneumonia, bacteremia, and complicated urinary tract infections, where other antimicrobial opt...

Systemic administration is typically reserved for hospitalized patients with life-threatening infections, such as hospital-acquired pneumonia, bacteremia, and complicated urinary tract infections, where other antimicrobial options are ineffective or contraindicated