Selective I(f) Current Inhibitors - SA Node

Selective I(f) current inhibitors of the sinoatrial (SA) node—predominantly classified in regulatory pharmacology as hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blockers—are cardiovascular agents that slow cardiac pacemaker automaticity They act by selectively inhibiting the mixed inward sodium-potassium hyperpolarization-activated funny current (I(f)) within SA node pacemaker cells, which prolongs diastolic depolarization and lowers heart rate without impairing ventricular...

Selective I(f) current inhibitors of the sinoatrial (SA) node—predominantly classified in regulatory pharmacology as hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blockers—are cardiovascular agents that slow cardiac pacemaker automaticity

They act by selectively inhibiting the mixed inward sodium-potassium hyperpolarization-activated funny current (I(f)) within SA node pacemaker cells, which prolongs diastolic depolarization and lowers heart rate without impairing ventricular repolarization, myocardial contractility, or vascular tone

They act by selectively inhibiting the mixed inward sodium-potassium hyperpolarization-activated funny current (I(f)) within SA node pacemaker cells, which prolongs diastolic depolarization and lowers heart rate without impairing ventricular repolarization, myocardial contractility, or vascular tone

Clinically exemplified by ivabradine, this class is utilized to reduce hospitalizations in patients with stable, symptomatic chronic heart failure with reduced ejection fraction and elevated resting sinus rhythm, and it is also established internationally for the management of chronic stable angina pectoris

Clinically exemplified by ivabradine, this class is utilized to reduce hospitalizations in patients with stable, symptomatic chronic heart failure with reduced ejection fraction and elevated resting sinus rhythm, and it is also established internationally for the management of chronic stable angina pectoris