Humate-P (antihemophilic factor, human/von Willebrand factor,human)

Antihemophilic Products Intravenous Vial (Ea)

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Last reviewed · Source: First Databank (FDB) drug data

Overview

Antihemophilic factor (human) is a preparation of antihemophilic factor (blood coagulation factor VIII) prepared from pooled human plasma. Antihemophilic factor/von Willebrand factor complex (human) is a preparation of antihemophilic factor and von Willebrand factor prepared from pooled human plasma.

USES: This product contains human factor VIII (also called antihemophilic factor) and von Willebrand factor complex. Factors are proteins normally found in the blood that help the blood to thicken (clot) and stop any bleeding. People with low levels of factor VIII and von Willebrand factor are at risk for bleeding longer after an injury/surgery and for bleeding inside the body (especially into the joints and muscles).

This product is used to temporarily replace the missing factors and reduce bleeding. Different brands of this product have different amounts of these factors, and so have different uses. These products are not interchangeable.

Do not change brands of this medication without the approval of your doctor. Some products are used to control and prevent bleeding episodes in people with low levels of factor VIII (hemophilia A). Some products are used to control and prevent bleeding episodes in people with low levels of von Willebrand factor (von Willebrand disease).

Some products are used to prevent excessive bleeding during and after surgery in patients with von Willebrand disease.

Generic name: antihemophilic factor, human/von Willebrand factor,human
Pronunciation: (FAK-tor VIII/von-WIL-e-brand FAK-tor)
Drug class: Antihemophilic Products
Therapeutic class: Hematological Agents

Reference product & biosimilars

No reference, biosimilar or interchangeable associated with this drug.

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Indications

The following indications are listed for Humate-P:

  • Acquired Factor Viii Deficiency Disease
  • Bleeding Episode In Acquired Factor Viii Deficiency Disease
  • Bleeding Episode In Hemophilia A
  • Bleeding Prevention In Von Willebrand Disease Type 3
  • Hemophilia A
  • Prevention Of Surgery-Induced Bleed In Von Willebrand's Disease
  • Von Willebrand's Disease

Also known as: Angiohemophilia, Bleeding Prophylaxis In Type 3 Von Willebrand Disease, Congenital Factor Viii Deficiency Disease, Constitutional Thrombopathy, Hemorrhaging In Hemophilia A, Pseudohemophilia, Vascular Hemophilia, Von Willebrand Disease, Willebrand-Juergens Disease.

Dosing

Dosage of antihemophilic factor (human) and antihemophilic factor/von Willebrand factor complex (human) is expressed in terms of international units (IU, units); 1 unit of antihemophilic factor is approximately equivalent to the amount of factor VIII in 1 mL of fresh pooled human plasma. In general, administration of 1 unit/kg of these antihemophilic factor preparations will increase the circulating factor VIII level by approximately 2 units/dL (2%).

Drug interactions

There is no enhanced messaging for this drug.

Contraindications

There is no enhanced messaging for this drug.

Adverse reactions

There is no enhanced messaging for this drug.

Precautions

No enhanced messaging available.

ICD codes

CodeTypeDescription
Acquired factor VIII deficiency disease
D68.311ICD10CMAcquired hemophilia
D68.4ICD10CMAcquired coagulation factor deficiency
Bleeding episode in acquired factor VIII deficiency disease
D68.311ICD10CMAcquired hemophilia
D68.4ICD10CMAcquired coagulation factor deficiency
Bleeding episode in hemophilia A
D66ICD10CMHereditary factor VIII deficiency
Z14.02ICD10CMSymptomatic hemophilia A carrier
Bleeding prevention in von willebrand disease type 3
D68.03ICD10CMVon willebrand disease, type 3
Hemophilia A
D66ICD10CMHereditary factor VIII deficiency
Z14.02ICD10CMSymptomatic hemophilia A carrier
Prevention of surgery-induced bleed in von willebrand's disease
D68.0ICD10CMVon willebrand disease
D68.00ICD10CMVon willebrand disease, unspecified
D68.01ICD10CMVon willebrand disease, type 1
D68.02ICD10CMVon willebrand disease, type 2
D68.020ICD10CMVon willebrand disease, type 2A
D68.021ICD10CMVon willebrand disease, type 2B
D68.022ICD10CMVon willebrand disease, type 2M
D68.023ICD10CMVon willebrand disease, type 2N
D68.029ICD10CMVon willebrand disease, type 2, unspecified
D68.03ICD10CMVon willebrand disease, type 3
D68.04ICD10CMAcquired von willebrand disease
D68.09ICD10CMOther von willebrand disease
Von willebrand's disease
D68.0ICD10CMVon willebrand disease
D68.00ICD10CMVon willebrand disease, unspecified
D68.01ICD10CMVon willebrand disease, type 1
D68.02ICD10CMVon willebrand disease, type 2
D68.020ICD10CMVon willebrand disease, type 2A
D68.021ICD10CMVon willebrand disease, type 2B
D68.022ICD10CMVon willebrand disease, type 2M
D68.023ICD10CMVon willebrand disease, type 2N
D68.029ICD10CMVon willebrand disease, type 2, unspecified
D68.03ICD10CMVon willebrand disease, type 3
D68.04ICD10CMAcquired von willebrand disease
D68.09ICD10CMOther von willebrand disease

ICD code information from First Databank (FDB).

Formulary status

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Last reviewed · Source: First Databank (FDB) drug data