Indication

Acquired factor VIII deficiency disease

Acquired factor VIII deficiency disease, also known as acquired hemophilia A, is a rare autoimmune bleeding disorder characterized by the spontaneous development of neutralizing autoantibodies directed against endogenous coagulation factor VIII. Read more about Acquired factor VIII deficiency disease

7 drugs 5 manufacturers

Advertisement

Drugs that treat it

Common Acquired factor VIII deficiency disease therapies.

Showing 1–7 of 7 drugs

Filter & compare in the drug finder →Opens the drug finder with Acquired factor VIII deficiency disease preselected.

News & literature

Coming soon

Related codes

Coming soon
Coming soon

About Acquired factor VIII deficiency disease.

Acquired factor VIII deficiency disease, also known as acquired hemophilia A, is a rare autoimmune bleeding disorder characterized by the spontaneous development of neutralizing autoantibodies directed against endogenous coagulation factor VIII.

This condition affects the hematologic and vascular systems in individuals without a personal or hereditary history of coagulopathy, occurring most frequently in older adults of either sex and occasionally in the postpartum setting or in association with underlying autoimmune diseases or malignancies.

Pathophysiologically, the antibody-mediated neutralization or clearance of factor VIII disrupts the intrinsic coagulation pathway, manifesting clinically as sudden, often severe or life-threatening mucocutaneous hemorrhage, extensive subcutaneous ecchymoses, deep soft-tissue or intramuscular hematomas, and prolonged activated partial thromboplastin time that fails to correct with normal plasma.

Personalize your experience

Follow Acquired factor VIII deficiency disease and get updates as they land.

Create a free account

Follow an indication and get alerts when its drugs, labels, or guidelines change

Save any drug on this page to your favorites, synced across devices

AI-curated peer-reviewed research, summarized for your specialty

A morning digest of indication-relevant updates, when you want it