Sodium Chloride (sodium chloride 0.45 %)
Parenteral Solutions Containing Sodium Injection Vial (ML); Intravenous Piggyback With Threaded Port (ML); Intravenous Vial (ML)
Last reviewed · Source: First Databank (FDB) drug data
Overview
Generic name: sodium chloride 0.45 %
Drug class: Parenteral Solutions Containing Sodium
Therapeutic class: Electrolyte Balance-Nutritional Products
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Sodium Chloride
Indications
No indications are available for this drug.
Dosing
No dosing information is available for this tab.
No dosing information is available for this tab.
No dosing information is available for this tab.
No dosing information is available for this tab.
Drug interactions
There is no enhanced messaging for this drug.
There are no contraindication interactions for this drug.
Severe Interaction: Action is required to reduce the risk of severe adverse interaction.
Hypertonic Saline/Vasopressin Antagonists
SEVERITY LEVEL: 2-Severe Interaction: Action is required to reduce the risk of severe adverse interaction.
MECHANISM OF ACTION: Concurrent administration of vasopressin antagonists and hypertonic saline may result in overly rapid correction of serum sodium levels.(1,2)
CLINICAL EFFECTS: Overly rapid correction of serum sodium levels may result in osmotic demyelination. Symptoms of osmotic demyelination include dysarthria, mutism, dysphagia, lethargy, affective changes, spastic quadriparesis, seizures, coma and/or death.(1,2)
PREDISPOSING FACTORS: Patients who are malnourished, have a history of alcoholism, and/or advanced liver disease may be more susceptible to adverse effects of overly rapid hyponatremia correction.(1,2)
PATIENT MANAGEMENT: Avoid the concurrent use of vasopressin antagonists and hypertonic saline. In patients who are malnourished, have a history of alcoholism, and/or advanced liver disease, use slower rates of sodium correction.(1,2)
DISCUSSION: Overly rapid correction of serum sodium levels may result in osmotic demyelination. Symptoms of osmotic demyelination include dysarthria, mutism, dysphagia, lethargy, affective changes, spastic quadriparesis, seizures, coma and/or death. Patients who are malnourished, have a history of alcoholism, and/or advanced liver disease may be more susceptible to adverse effects of overly rapid hyponatremia correction. Avoid the concurrent use of vasopressin antagonists and hypertonic saline. In patients who are malnourished, have a history of alcoholism, and/or advanced liver disease, use slower rates of sodium correction.(1,2)
There are no moderate interactions for this drug.
Contraindications
There is no enhanced messaging for this drug.
There are no contraindication contraindications for this drug.
There are no severe contraindications for this drug.
There are no moderate contraindications for this drug.
Adverse reactions
There is no enhanced messaging for this drug.
There are no severe adverse reactions for this drug.
There are no less severe adverse reactions for this drug.
Precautions
No enhanced messaging available.
No enhanced messaging available.
No enhanced messaging available.
No enhanced messaging available.
No enhanced messaging available.
ICD codes
| Code | Type | Description |
|---|---|---|
| Hyponatremia | ||
| E87.1 | ICD10CM | Hypo-osmolality and hyponatremia |
ICD code information from First Databank (FDB).
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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