Azulfidine (sulfasalazine)

Last reviewed October 24, 2026 · Source: First Databank (FDB) drug data

Overview

Sulfasalazine, a sulfonamide, generally is considered a prodrug since the diazo bond is cleaved in vivo to provide sulfapyridine and 5-aminosalicyclic acid (mesalamine); the drug exhibits antibacterial and anti-inflammatory activity.

Sulfasalazine is used for the management of mild to moderate ulcerative colitis in adults and children 2 years of age or older and also has been used in the management of Crohn's disease+ in adult and pediatric patients. In addition, sulfasalazine administered as delayed-release tablets is used for the management of rheumatoid arthritis in adults and for the management of polyarticular course juvenile rheumatoid arthritis in children 6-16 years of age.

Generic name: sulfasalazine
Pronunciation: (sull-fuh-SAL-uh-zeen)

Reference product & biosimilars

No reference, biosimilar or interchangeable associated with this drug.

Today’s intelligence on Azulfidine

Intelligence content is not available yet.

Indications

The following indications are listed for Azulfidine:

Ulcerative Colitis
Ulcerative Colitis Remission

Also known as: Colitis Ulcerativa, Colitis Ulcerativa In Remission, Ulcerative Colitis In Remission.

Dosing

No dosing information is available for this tab.

Drug interactions

Sulfasalazine shares the potential drug interactions of the sulfonamides. In addition, sulfasalazine may interact with other agents.

It has been postulated that concomitant use of anti-infectives may alter the action of sulfasalazine by altering intestinal flora and consequently sulfasalazine metabolism.

Contraindications

There is no enhanced messaging for this drug.

Adverse reactions

There is no enhanced messaging for this drug.

Precautions

No enhanced messaging available.

ICD codes

No ICD codes are available for this drug.

Formulary status

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