Azulfidine (sulfasalazine)
Last reviewed · Source: First Databank (FDB) drug data
Overview
Sulfasalazine, a sulfonamide, generally is considered a prodrug since the diazo bond is cleaved in vivo to provide sulfapyridine and 5-aminosalicyclic acid (mesalamine); the drug exhibits antibacterial and anti-inflammatory activity.
Sulfasalazine is used for the management of mild to moderate ulcerative colitis in adults and children 2 years of age or older and also has been used in the management of Crohn's disease+ in adult and pediatric patients. In addition, sulfasalazine administered as delayed-release tablets is used for the management of rheumatoid arthritis in adults and for the management of polyarticular course juvenile rheumatoid arthritis in children 6-16 years of age.
Generic name: sulfasalazine
Pronunciation: (sull-fuh-SAL-uh-zeen)
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Azulfidine
Indications
The following indications are listed for Azulfidine:
- Polyarticular Juvenile Idiopathic Arthritis
- Rheumatoid Arthritis
- Ulcerative Colitis
- Ulcerative Colitis Remission
Also known as: Arthritis Deformans, Arthrosis Deformans, Colitis Ulcerativa, Colitis Ulcerativa In Remission, Nodose Rheumatism, Polyarticular Jia, Polyarticular Jra, Polyarticular Juvenile Chronic Arthritis, Polyarticular Juvenile Rheumatoid Arthritis, Rheumatic Arthritis, Rheumatic Gout, Ulcerative Colitis In Remission.
Dosing
No dosing information is available for this tab.
Sulfasalazine conventional and delayed-release tablets are administered orally. The total daily dosage should be divided into equally divided doses, and, if possible, doses should be administered after meals.
Delayed-release sulfasalazine tablets should be swallowed whole.
No dosing information is available for this tab.
No dosing information is available for this tab.
Drug interactions
Sulfasalazine shares the potential drug interactions of the sulfonamides. In addition, sulfasalazine may interact with other agents.
It has been postulated that concomitant use of anti-infectives may alter the action of sulfasalazine by altering intestinal flora and consequently sulfasalazine metabolism.
There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
There is no enhanced messaging for this drug.
There are no contraindication contraindications for this drug.
There are no severe contraindications for this drug.
There are no moderate contraindications for this drug.
Adverse reactions
There is no enhanced messaging for this drug.
There are no severe adverse reactions for this drug.
There are no less severe adverse reactions for this drug.
Precautions
No enhanced messaging available.
No enhanced messaging available.
No enhanced messaging available.
No enhanced messaging available.
No enhanced messaging available.
ICD codes
No ICD codes are available for this drug.
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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