Difmetioxrime (fluconazole/ibuprofen/itraconazole/terbinafine HCl)
Topical Antifungals Topical Solution, Non-Oral
Last reviewed · Source: First Databank (FDB) drug data
Overview
Generic name: fluconazole/ibuprofen/itraconazole/terbinafine HCl
Drug class: Topical Antifungals
Therapeutic class: Dermatological
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Difmetioxrime
Indications
No indications are available for this drug.
Dosing
No dosing information is available for this tab.
No dosing information is available for this tab.
No dosing information is available for this tab.
No dosing information is available for this tab.
Drug interactions
There is no enhanced messaging for this drug.
There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
There is no enhanced messaging for this drug.
- Aspirin exacerbated respiratory disease
- Cerebrovascular accident
- History of roux-en-Y gastric bypass
- Post-operative from CABG surgery
- Pregnancy
- Renal transplant
- Acute myocardial infarction
- Alcohol use disorder
- Chronic kidney disease stage 4 (severe) GFR 15-29 ml/min
- Chronic kidney disease stage 5 (failure) GFr<15 ml/min
- CYp2c9 intermediate metabolizer (activity score 1)
- CYp2c9 poor metabolizer
- Gastrointestinal perforation
- Gastrointestinal ulcer
- Hemorrhage
- History of kidney donation
- Increased risk of bleeding
- Nephrectomy
- Systemic mastocytosis
- Thrombotic disorder
- Chronic heart failure
- Disease of liver
- Hypertension
- Kidney disease with likely reduction in glomerular filtration rate (GFr)
- No disease contraindications
- Tobacco smoker
Adverse reactions
There is no enhanced messaging for this drug.
More Frequent
- Skin rash
Less Frequent
- Pruritus of skin
Rare or Very Rare
- Anaphylaxis
- Angioedema
- Asthma exacerbation
- Blistering skin
- Bronchospastic pulmonary disease
- Bullous dermatitis
- Dyspnea
- Erythema
- Erythema multiforme
- Paresthesia
- Pruritus of skin
- Purpura
- Skin inflammation
- Skin irritation
- Toxic epidermal necrolysis
- Urticaria
More Frequent
- Abdominal pain with cramps
Less Frequent
- Dyspepsia
Precautions
No enhanced messaging available.
No enhanced messaging available.
No enhanced messaging available.
No enhanced messaging available.
No enhanced messaging available.
ICD codes
No ICD codes are available for this drug.
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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