Metdray (salicylic acid/ibuprofen)

No dosing information is available for this tab.

Salicylic acid is applied topically to the skin as a cake, cream, gel, lotion, ointment, pledget, plaster, shampoo, solution, or suspension. Topical preparations of salicylic acid are for external use only. Contact with the eyes should be avoided; if contact occurs, the affected eye(s) should be washed thoroughly with water.

Prior to topical application, the affected area(s) to be treated should be cleansed and allowed to dry. Prior to removal of warts, corns, and calluses, the affected area may be soaked in warm water for 5 minutes.

Salicylic acid is commercially available in various preparations, some of which are intended for self-medication; the manufacturer's product labeling should be consulted for complete directions regarding appropriate dosage and administration of specific products.

No dosing information is available for this tab.

No dosing information is available for this tab.

There is no enhanced messaging for this drug.

There are no contraindication interactions for this drug.

There are no severe interactions for this drug.

There are no moderate interactions for this drug.

There is no enhanced messaging for this drug.

• Aspirin exacerbated respiratory disease
• Cerebrovascular accident
• Hemolytic anemia from pyruvate kinase and g6PD deficiencies
• History of roux-en-Y gastric bypass
• Post-operative from CABG surgery
• Pregnancy
• Renal transplant

• Acute myocardial infarction
• Alcohol use disorder
• Chronic kidney disease stage 4 (severe) GFR 15-29 ml/min
• Chronic kidney disease stage 5 (failure) GFr<15 ml/min
• CYp2c9 intermediate metabolizer (activity score 1)
• CYp2c9 poor metabolizer
• Gastrointestinal perforation
• Gastrointestinal ulcer
• Hemorrhage
• History of kidney donation
• Increased risk of bleeding
• Nephrectomy
• Systemic mastocytosis
• Thrombotic disorder

• Chronic heart failure
• Disease of liver
• Hypertension
• Kidney disease with likely reduction in glomerular filtration rate (GFr)
• Peripheral vascular disease
• Tobacco smoker

There is no enhanced messaging for this drug.

More Frequent

• Skin rash

Less Frequent

• Pruritus of skin

Rare or Very Rare

• Anaphylaxis
• Anaphylaxis
• Angioedema
• Asthma exacerbation
• Bronchospastic pulmonary disease
• Bullous dermatitis
• Burns
• Dyspnea
• Dyspnea
• Erythema multiforme
• Facial edema
• Hypersensitivity drug reaction
• Periorbital edema
• Pharyngeal edema
• Purpura
• Skin ulcer
• Superficial skin ulcer
• Syncope
• Throat constriction
• Toxic epidermal necrolysis
• Urticaria
• Urticaria

More Frequent

• Abdominal pain with cramps
• Stinging of skin

Less Frequent

• Dry skin
• Dyspepsia
• Skin irritation

Rare or Very Rare

• Pruritus of skin

No enhanced messaging available.

No enhanced messaging available.

There are no adequate and well-controlled studies of topical salicylic acid in pregnant women; the drug should be used during pregnancy only if the potential benefits justify the possible risks to the fetus.

Because of the potential for serious adverse reactions to salicylic acid in nursing infants, a decision should be made whether to discontinue nursing or the drug, taking into account the importance of the drug to the woman. If used in nursing women, the drug should not be applied to the chest area to avoid accidental contamination of the infant.

No enhanced messaging available.