Abortion with sepsis

Abortion with sepsis is a life-threatening obstetric and gynecologic emergency characterized by an intrauterine infection that develops shortly before, during, or after a spontaneous or induced abortion and progresses to systemic infection It primarily affects pregnant or recently pregnant individuals, frequently arising from retained products of conception or instrumentation performed under nonsterile conditions

Abortion with sepsis is a life-threatening obstetric and gynecologic emergency characterized by an intrauterine infection that develops shortly before, during, or after a spontaneous or induced abortion and progresses to systemic infection It primarily affects pregnant or recently pregnant individuals, frequently arising from retained products of conception or instrumentation performed under nonsterile conditions Pathophysiologically, ascending polymicrobial pathogens—including enteric gram-nega...

Pathophysiologically, ascending polymicrobial pathogens—including enteric gram-negative bacilli, anaerobic bacteria, and streptococci—invade the endometrium, parametrium, or maternal vascular spaces, triggering bacteremia and dysregulated host systemic inflammatory cascades

Defining clinical features include fever, pelvic pain, purulent vaginal discharge, uterine tenderness, and vaginal bleeding, with the potential to rapidly advance to hemodynamic instability, septic shock, disseminated intravascular coagulation, or multi-organ failure