BOSULIF (bosutinib)
ANTINEOPLASTIC - PROTEIN-TYROSINE KINASE INHIBITORS·LYMPHOID BLAST PHASE PHILADELPHIA CHROMOSOME POSITIVE CHRONIC MYELOCYTIC LEUKEMIA·+3
Laboratories Div
Indication
Accelerated phase Philadelphia chromosome positive chronic myelocytic leukemia
Accelerated phase Philadelphia chromosome-positive chronic myelocytic leukemia is an advanced, transitional stage of a clonal myeloproliferative neoplasm affecting hematopoietic stem cells in the bone marrow and peripheral blood. Read more about Accelerated phase Philadelphia chromosome positive chronic myelocytic leukemia
56 drugs 40 manufacturers
Drugs that treat it
Common Accelerated phase Philadelphia chromosome positive chronic myelocytic leukemia therapies.
DANZITEN (nilotinib tartrate)
ANTINEOPLASTIC - PROTEIN-TYROSINE KINASE INHIBITORS·CHRONIC PHASE PHILADELPHIA CHROMOSOME POSITIVE CHRONIC MYELOCYTIC LEUKEMIA·+1
SILVERGATE PHAR
DASATINIB
ANTINEOPLASTIC - PROTEIN-TYROSINE KINASE INHIBITORS·PHILADELPHIA CHROMOSOME POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA·+4
DR.REDDY'S LAB
IMATINIB MESYLATE
ANTINEOPLASTIC - PROTEIN-TYROSINE KINASE INHIBITORS·PHILADELPHIA CHROMOSOME POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA·+11
AREVA PHARMACEU
IMATINIB MESYLATE
ANTINEOPLASTIC - PROTEIN-TYROSINE KINASE INHIBITORS·PHILADELPHIA CHROMOSOME POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA·+11
GSMS, INC.
DASATINIB
ANTINEOPLASTIC - PROTEIN-TYROSINE KINASE INHIBITORS·PHILADELPHIA CHROMOSOME POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA·+4
APOTEX CORP
IMATINIB MESYLATE
ANTINEOPLASTIC - PROTEIN-TYROSINE KINASE INHIBITORS·PHILADELPHIA CHROMOSOME POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA·+11
CHARTWELL RX LL
IMATINIB MESYLATE
ANTINEOPLASTIC - PROTEIN-TYROSINE KINASE INHIBITORS·PHILADELPHIA CHROMOSOME POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA·+11
AHP
IMATINIB MESYLATE
ANTINEOPLASTIC - PROTEIN-TYROSINE KINASE INHIBITORS·PHILADELPHIA CHROMOSOME POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA·+11
AUROBINDO PHARM
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Coming soonAccelerated phase Philadelphia chromosome-positive chronic myelocytic leukemia is an advanced, transitional stage of a clonal myeloproliferative neoplasm affecting hematopoietic stem cells in the bone marrow and peripheral blood.
It is pathologically driven by the BCR::ABL1 fusion gene resulting from the reciprocal t(9;22)(q34;q11) translocation, known as the Philadelphia chromosome, which encodes a constitutively active tyrosine kinase.
The accelerated phase represents disease evolution beyond the indolent chronic phase toward acute blast transformation, characterized clinically by treatment-refractory leukocytosis or splenomegaly, elevated blast counts (typically 10% to 19%), persistent thrombocytosis or thrombocytopenia, prominent basophilia, and frequent cytogenetic clonal evolution.
- nih.gov
Accelerated phase Philadelphia chromosome-positive chronic myelocytic leukemia is an advanced, transitional stage of a clonal myeloproliferative neoplasm affecting hematopoietic stem cells in the bone marrow and peripheral blood It is pathologically driven by the BCR::ABL1 fusion gene resulting from the reciprocal t(9;22)(q34;q11) translocation, known as the Philadelphia chromosome, which encodes a constitutively active tyrosine kinase
- nih.gov
Accelerated phase Philadelphia chromosome-positive chronic myelocytic leukemia is an advanced, transitional stage of a clonal myeloproliferative neoplasm affecting hematopoietic stem cells in the bone marrow and peripheral blood The accelerated phase represents disease evolution beyond the indolent chronic phase toward acute blast transformation, characterized clinically by treatment-refractory leukocytosis or splenomegaly, elevated blast counts (typically 10% to 19%), persistent thrombocytosis ...
- nih.gov
It is pathologically driven by the BCR::ABL1 fusion gene resulting from the reciprocal t(9;22)(q34;q11) translocation, known as the Philadelphia chromosome, which encodes a constitutively active tyrosine kinase
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