Acinetobacter pneumonia

Acinetobacter pneumonia is a severe lower respiratory tract infection caused by aerobic, Gram-negative coccobacilli of the genus *Acinetobacter*, predominantly the *Acinetobacter baumannii* complex The disease most frequently manifests as hospital-acquired pneumonia or ventilator-associated pneumonia among critically ill, mechanically ventilated, or immunocompromised patients in intensive care units Clinically, it is characterized by new or progressive pulmonary infiltrates, purulent sputum prod...

Acinetobacter pneumonia is a severe lower respiratory tract infection caused by aerobic, Gram-negative coccobacilli of the genus *Acinetobacter*, predominantly the *Acinetobacter baumannii* complex The disease most frequently manifests as hospital-acquired pneumonia or ventilator-associated pneumonia among critically ill, mechanically ventilated, or immunocompromised patients in intensive care units Pathophysiologically, it develops following bacterial colonization of the upper airway and subseq...

Pathophysiologically, it develops following bacterial colonization of the upper airway and subsequent aspiration into the pulmonary parenchyma, where capsular polysaccharides, endotoxins, and robust biofilm formation drive intense alveolar inflammation, tissue necrosis, and acute respiratory failure

Clinically, it is characterized by new or progressive pulmonary infiltrates, purulent sputum production, hypoxemia, fever, and a pronounced propensity for multidrug resistance and hemodynamic instability