Acromegaly

Acromegaly is a rare, chronic endocrine disorder characterized by the autonomous hypersecretion of growth hormone (GH) following epiphyseal plate closure in adulthood, driven in most cases by a benign anterior pituitary adenoma Excess circulating GH stimulates the liver and peripheral tissues to overproduce insulin-like growth factor 1 (IGF-1), resulting in progressive somatic and soft-tissue overgrowth Patients classically develop coarse facial features, prognathism, macroglossia, and enlargeme...

Acromegaly is a rare, chronic endocrine disorder characterized by the autonomous hypersecretion of growth hormone (GH) following epiphyseal plate closure in adulthood, driven in most cases by a benign anterior pituitary adenoma Excess circulating GH stimulates the liver and peripheral tissues to overproduce insulin-like growth factor 1 (IGF-1), resulting in progressive somatic and soft-tissue overgrowth

Acromegaly is a rare, chronic endocrine disorder characterized by the autonomous hypersecretion of growth hormone (GH) following epiphyseal plate closure in adulthood, driven in most cases by a benign anterior pituitary adenoma Excess circulating GH stimulates the liver and peripheral tissues to overproduce insulin-like growth factor 1 (IGF-1), resulting in progressive somatic and soft-tissue overgrowth If unaddressed, sustained hormone elevation contributes to multi-organ system complications, ...

Excess circulating GH stimulates the liver and peripheral tissues to overproduce insulin-like growth factor 1 (IGF-1), resulting in progressive somatic and soft-tissue overgrowth If unaddressed, sustained hormone elevation contributes to multi-organ system complications, prominently including hypertension, cardiomyopathy, obstructive sleep apnea, type 2 diabetes mellitus, and osteoarthritis

Patients classically develop coarse facial features, prognathism, macroglossia, and enlargement of the hands and feet

If unaddressed, sustained hormone elevation contributes to multi-organ system complications, prominently including hypertension, cardiomyopathy, obstructive sleep apnea, type 2 diabetes mellitus, and osteoarthritis