Acute exacerbation of multiple sclerosis

An acute exacerbation of multiple sclerosis—also termed a relapse, attack, or flare—is a sudden clinical worsening characterized by the emergence of new neurological symptoms or the intensification of preexisting deficits lasting at least 24 hours in the absence of fever, infection, or metabolic disturbance

An acute exacerbation of multiple sclerosis—also termed a relapse, attack, or flare—is a sudden clinical worsening characterized by the emergence of new neurological symptoms or the intensification of preexisting deficits lasting at least 24 hours in the absence of fever, infection, or metabolic disturbance

This acute state primarily affects adults and youth living with relapsing forms of multiple sclerosis, involving inflammatory damage to the central nervous system Pathophysiologically, it is driven by focal, immune-mediated breakdown of the blood-brain barrier resulting in perivascular infiltration of lymphocytes, acute demyelination, and axonal injury within the brain, optic nerves, or spinal cord Patients commonly present with acute unilateral optic neuritis, focal motor weakness, sensory dist...

This acute state primarily affects adults and youth living with relapsing forms of multiple sclerosis, involving inflammatory damage to the central nervous system

Pathophysiologically, it is driven by focal, immune-mediated breakdown of the blood-brain barrier resulting in perivascular infiltration of lymphocytes, acute demyelination, and axonal injury within the brain, optic nerves, or spinal cord