Amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis is a progressive, fatal neurodegenerative disorder characterized by the selective degeneration and death of upper motor neurons in the cerebral cortex and lower motor neurons in the brainstem and spinal cord Clinically, the disease manifests with a combination of lower motor neuron features, such as progressive muscle weakness, wasting, cramps, and fasciculations, along with upper motor neuron signs like spasticity and hyperreflexia As the pathology spreads through ...

Amyotrophic lateral sclerosis is a progressive, fatal neurodegenerative disorder characterized by the selective degeneration and death of upper motor neurons in the cerebral cortex and lower motor neurons in the brainstem and spinal cord

Primarily affecting adults—most commonly presenting between 55 and 75 years of age—it leads to the interruption of neural signaling to voluntary muscles Clinically, the disease manifests with a combination of lower motor neuron features, such as progressive muscle weakness, wasting, cramps, and fasciculations, along with upper motor neuron signs like spasticity and hyperreflexia As the pathology spreads through spinal and bulbar motor circuits, patients experience worsening limb paralysis, dysar...

Primarily affecting adults—most commonly presenting between 55 and 75 years of age—it leads to the interruption of neural signaling to voluntary muscles