Anaphylaxis

Anaphylaxis is an acute, life-threatening, multisystem hypersensitivity reaction that progresses rapidly and can affect pediatric and adult populations alike

Anaphylaxis is an acute, life-threatening, multisystem hypersensitivity reaction that progresses rapidly and can affect pediatric and adult populations alike It typically occurs following exposure to an inciting allergen—most commonly foods, medications, or insect venom—which triggers systemic mast cell and basophil activation via immunoglobulin E (IgE)–mediated or non-IgE–mediated pathways This explosive activation releases potent inflammatory mediators, including histamine, tryptase, and leuko...

This explosive activation releases potent inflammatory mediators, including histamine, tryptase, and leukotrienes, driving increased vascular permeability, massive vasodilation, and smooth muscle contraction Clinically, it manifests with sudden compromise of the respiratory system (such as bronchospasm, stridor, or laryngeal edema), cardiovascular system (profound hypotension, syncope, or vascular collapse), skin and mucosa (urticaria, flushing, and angioedema), or gastrointestinal tract

Clinically, it manifests with sudden compromise of the respiratory system (such as bronchospasm, stridor, or laryngeal edema), cardiovascular system (profound hypotension, syncope, or vascular collapse), skin and mucosa (urticaria, flushing, and angioedema), or gastrointestinal tract