Atopic dermatitis

Atopic dermatitis is a chronic, relapsing inflammatory disorder of the skin and the most common type of eczema

Atopic dermatitis is a chronic, relapsing inflammatory disorder of the skin and the most common type of eczema While it predominantly presents during infancy and early childhood, it can affect individuals of any age and frequently co-occurs with other atopic manifestations such as asthma and allergic rhinitis Pathophysiologically, the condition arises from a complex interplay of epidermal barrier disruption, altered cutaneous immune activation primarily involving type 2 cytokine signaling, and m...

While it predominantly presents during infancy and early childhood, it can affect individuals of any age and frequently co-occurs with other atopic manifestations such as asthma and allergic rhinitis

While it predominantly presents during infancy and early childhood, it can affect individuals of any age and frequently co-occurs with other atopic manifestations such as asthma and allergic rhinitis Clinically, it is characterized by intense pruritus, xerosis, and erythematous or scaly eczematous lesions that favor extensor surfaces in infants and flexural creases in older children and adults, often progressing to lichenification with chronic scratching

Pathophysiologically, the condition arises from a complex interplay of epidermal barrier disruption, altered cutaneous immune activation primarily involving type 2 cytokine signaling, and microbial dysbiosis

Clinically, it is characterized by intense pruritus, xerosis, and erythematous or scaly eczematous lesions that favor extensor surfaces in infants and flexural creases in older children and adults, often progressing to lichenification with chronic scratching