Biotin deficiency

Biotin deficiency is a nutritional and metabolic disorder resulting from inadequate biological availability of biotin (vitamin B7), a vital water-soluble cofactor required by carboxylase enzymes involved in fatty acid synthesis, gluconeogenesis, and amino acid catabolism It can arise from acquired factors—such as unsupplemented parenteral nutrition, prolonged anticonvulsant therapy, or excessive raw egg white consumption—or from inborn errors of metabolism, notably biotinidase or holocarboxylase...

Biotin deficiency is a nutritional and metabolic disorder resulting from inadequate biological availability of biotin (vitamin B7), a vital water-soluble cofactor required by carboxylase enzymes involved in fatty acid synthesis, gluconeogenesis, and amino acid catabolism

It can arise from acquired factors—such as unsupplemented parenteral nutrition, prolonged anticonvulsant therapy, or excessive raw egg white consumption—or from inborn errors of metabolism, notably biotinidase or holocarboxylase synthetase deficiencies Characteristic clinical hallmarks include thinning hair, progressive alopecia, and an erythematous, periorificial scaly dermatitis, frequently progressing to neurologic manifestations such as hypotonia, ataxia, paresthesias, seizures, and metaboli...

The condition primarily impacts the integumentary and nervous systems across pediatric and adult populations Characteristic clinical hallmarks include thinning hair, progressive alopecia, and an erythematous, periorificial scaly dermatitis, frequently progressing to neurologic manifestations such as hypotonia, ataxia, paresthesias, seizures, and metabolic ketoacidosis