Boutonneuse fever

Boutonneuse fever, also known as Mediterranean spotted fever, is a zoonotic tick-borne infection caused by the obligate intracellular bacterium *Rickettsia conorii* and transmitted primarily by the brown dog tick (*Rhipicephalus sanguineus*) Clinically, it affects individuals exposed in endemic regions—such as the Mediterranean basin, parts of Africa, and the Indian subcontinent—and typically presents with an abrupt onset of high fever, flu-like symptoms, a characteristic necrotic inoculation es...

Boutonneuse fever, also known as Mediterranean spotted fever, is a zoonotic tick-borne infection caused by the obligate intracellular bacterium *Rickettsia conorii* and transmitted primarily by the brown dog tick (*Rhipicephalus sanguineus*) Clinically, it affects individuals exposed in endemic regions—such as the Mediterranean basin, parts of Africa, and the Indian subcontinent—and typically presents with an abrupt onset of high fever, flu-like symptoms, a characteristic necrotic inoculation es...

Pathophysiologically, the organism invades and proliferates within vascular endothelial cells, causing systemic microvascular injury and widespread perivascular inflammation

Clinically, it affects individuals exposed in endemic regions—such as the Mediterranean basin, parts of Africa, and the Indian subcontinent—and typically presents with an abrupt onset of high fever, flu-like symptoms, a characteristic necrotic inoculation eschar known as a "tache noire" at the tick bite site, and a centripetally spreading maculopapular rash that often involves the palms and soles