Chronic eosinophilic leukemia

Chronic eosinophilic leukemia is a rare myeloproliferative neoplasm characterized by the autonomous, clonal overproduction of eosinophils within the bone marrow, peripheral blood, and tissues

Primarily affecting adults, the disease involves persistent hypereosinophilia accompanied by cytogenetic abnormalities, somatic driver mutations, or elevated blast counts, while excluding reactive causes and distinct myeloid neoplasms defined by rearrangements such as *PDGFRA*, *PDGFRB*, *FGFR1*, or *PCM1::JAK2*

Primarily affecting adults, the disease involves persistent hypereosinophilia accompanied by cytogenetic abnormalities, somatic driver mutations, or elevated blast counts, while excluding reactive causes and distinct myeloid neoplasms defined by rearrangements such as *PDGFRA*, *PDGFRB*, *FGFR1*, or *PCM1::JAK2* Widespread infiltration of tissues by mature and immature eosinophils releases cytotoxic granules, commonly causing organ dysfunction and damage across the cardiovascular system, central...

Widespread infiltration of tissues by mature and immature eosinophils releases cytotoxic granules, commonly causing organ dysfunction and damage across the cardiovascular system, central nervous system, lungs, skin, and gastrointestinal tract