Chronic heart failure following myocardial infarction

Chronic heart failure following myocardial infarction is a progressive cardiovascular syndrome characterized by the persistent inability of the heart to maintain adequate systemic perfusion

Affecting patients with prior ischemic myocardial injury, it develops primarily due to irreversible cardiomyocyte loss, infarct scar formation, and adverse ventricular remodeling that precipitates left ventricular systolic or combined dysfunction Clinically, affected individuals experience chronic exertional dyspnea, fatigue, reduced exercise tolerance, and signs of systemic or pulmonary venous congestion

Affecting patients with prior ischemic myocardial injury, it develops primarily due to irreversible cardiomyocyte loss, infarct scar formation, and adverse ventricular remodeling that precipitates left ventricular systolic or combined dysfunction Pathophysiologically, ongoing neurohormonal activation—including the renin-angiotensin-aldosterone and sympathetic nervous systems—drives progressive ventricular dilation, chamber wall thinning, and myocardial fibrosis

Pathophysiologically, ongoing neurohormonal activation—including the renin-angiotensin-aldosterone and sympathetic nervous systems—drives progressive ventricular dilation, chamber wall thinning, and myocardial fibrosis Clinically, affected individuals experience chronic exertional dyspnea, fatigue, reduced exercise tolerance, and signs of systemic or pulmonary venous congestion