Clostridium endometritis

Clostridium endometritis is an acute, potentially fulminant infection and inflammation of the endometrium caused by anaerobic, spore-forming bacteria of the genus *Clostridium* (most notably *Clostridium perfringens* or *Clostridium sordellii*) Pathophysiologically, the bacteria colonize disrupted or necrotic uterine tissue and release potent exotoxins, leading to rapid tissue destruction, marked uterine tenderness, purulent or malodorous vaginal discharge, and high fever

Clostridium endometritis is an acute, potentially fulminant infection and inflammation of the endometrium caused by anaerobic, spore-forming bacteria of the genus *Clostridium* (most notably *Clostridium perfringens* or *Clostridium sordellii*) This condition primarily affects the female reproductive tract in obstetric or gynecologic populations following childbirth, spontaneous or induced abortion, or instrumentation of the uterine cavity Pathophysiologically, the bacteria colonize disrupted or...

This condition primarily affects the female reproductive tract in obstetric or gynecologic populations following childbirth, spontaneous or induced abortion, or instrumentation of the uterine cavity

This condition primarily affects the female reproductive tract in obstetric or gynecologic populations following childbirth, spontaneous or induced abortion, or instrumentation of the uterine cavity

Pathophysiologically, the bacteria colonize disrupted or necrotic uterine tissue and release potent exotoxins, leading to rapid tissue destruction, marked uterine tenderness, purulent or malodorous vaginal discharge, and high fever

Left unchecked, the infection can progress aggressively through the myometrium, causing necrotizing myometritis, gas gangrene, severe systemic toxin-mediated capillary leak, intravascular hemolysis, and life-threatening septic shock