Common variable agammaglobulinemia

Common variable agammaglobulinemia, widely referred to in modern clinical practice as common variable immunodeficiency (CVID), is a heterogeneous primary antibody deficiency syndrome

Common variable agammaglobulinemia, widely referred to in modern clinical practice as common variable immunodeficiency (CVID), is a heterogeneous primary antibody deficiency syndrome

It primarily compromises the humoral immune system, affecting both children and adults, with clinical onset most frequently identified in the second through fourth decades of life Clinically, affected individuals suffer from recurrent sinopulmonary bacterial infections, bronchiectasis, gastrointestinal disease, and a heightened vulnerability to autoimmune disorders, granulomatous inflammation, and lymphoid malignancies

The condition is pathologically defined by defective B-cell differentiation resulting in markedly reduced serum IgG concentrations along with low IgA and/or IgM, accompanied by impaired or absent specific antibody responses to protein and polysaccharide antigens despite normal or near-normal circulating B-cell numbers

The condition is pathologically defined by defective B-cell differentiation resulting in markedly reduced serum IgG concentrations along with low IgA and/or IgM, accompanied by impaired or absent specific antibody responses to protein and polysaccharide antigens despite normal or near-normal circulating B-cell numbers

Clinically, affected individuals suffer from recurrent sinopulmonary bacterial infections, bronchiectasis, gastrointestinal disease, and a heightened vulnerability to autoimmune disorders, granulomatous inflammation, and lymphoid malignancies

Clinically, affected individuals suffer from recurrent sinopulmonary bacterial infections, bronchiectasis, gastrointestinal disease, and a heightened vulnerability to autoimmune disorders, granulomatous inflammation, and lymphoid malignancies