Congenital neurosyphilis

Congenital neurosyphilis is a severe complication of congenital syphilis resulting from the vertical transplacental transmission of the spirochete bacterium *Treponema pallidum* from an infected mother to the developing fetus Diagnosis is characterized by abnormal cerebrospinal fluid findings, including elevated white blood cell counts, elevated protein concentrations, or a reactive cerebrospinal fluid non-treponemal antibody test

Congenital neurosyphilis is a severe complication of congenital syphilis resulting from the vertical transplacental transmission of the spirochete bacterium *Treponema pallidum* from an infected mother to the developing fetus

It affects the central nervous system of neonates, infants, and older children, potentially manifesting in either early or late stages of the disease

It affects the central nervous system of neonates, infants, and older children, potentially manifesting in either early or late stages of the disease Defining pathophysiologic and clinical features include spirochetal invasion of the meninges and cerebral vasculature, which may present as aseptic meningitis, cranial nerve palsies, seizures, developmental delay, or hydrocephalus Diagnosis is characterized by abnormal cerebrospinal fluid findings, including elevated white blood cell counts, elevat...

Defining pathophysiologic and clinical features include spirochetal invasion of the meninges and cerebral vasculature, which may present as aseptic meningitis, cranial nerve palsies, seizures, developmental delay, or hydrocephalus