Diabetic ketoacidosis

Diabetic ketoacidosis is an acute, life-threatening metabolic emergency that predominantly affects individuals with type 1 diabetes mellitus, though it may also develop in patients with type 2 diabetes during acute illness or physiological stress

Diabetic ketoacidosis is an acute, life-threatening metabolic emergency that predominantly affects individuals with type 1 diabetes mellitus, though it may also develop in patients with type 2 diabetes during acute illness or physiological stress

Arising from an absolute or relative insulin deficiency paired with an excess of counterregulatory hormones, the systemic endocrine condition triggers uncontrolled lipolysis and hepatic fatty acid oxidation

Arising from an absolute or relative insulin deficiency paired with an excess of counterregulatory hormones, the systemic endocrine condition triggers uncontrolled lipolysis and hepatic fatty acid oxidation

It is classically characterized by the biochemical triad of hyperglycemia, high-anion-gap metabolic acidosis, and hyperketonemia

It is classically characterized by the biochemical triad of hyperglycemia, high-anion-gap metabolic acidosis, and hyperketonemia

Clinically, affected patients present with osmotic diuresis, dehydration, electrolyte derangements, nausea, abdominal pain, and Kussmaul respirations due to respiratory compensation for profound metabolic acidosis

Clinically, affected patients present with osmotic diuresis, dehydration, electrolyte derangements, nausea, abdominal pain, and Kussmaul respirations due to respiratory compensation for profound metabolic acidosis

Clinically, affected patients present with osmotic diuresis, dehydration, electrolyte derangements, nausea, abdominal pain, and Kussmaul respirations due to respiratory compensation for profound metabolic acidosis