Diarrhea associated with vasoactive intestinal peptide (VIP)-secreting tumor

Diarrhea associated with a vasoactive intestinal peptide (VIP)-secreting tumor is a severe, profuse secretory diarrhea caused by autonomous, unregulated humoral secretion from a neuroendocrine neoplasm (VIPoma), which most commonly arises from the non-beta islet cells of the pancreas or occasionally from neural crest tissues This condition manifests in affected patients as copious, tea-colored watery stools—persisting despite fasting—and classically leads to profound hypokalemia, hypochlorhydria...

Diarrhea associated with a vasoactive intestinal peptide (VIP)-secreting tumor is a severe, profuse secretory diarrhea caused by autonomous, unregulated humoral secretion from a neuroendocrine neoplasm (VIPoma), which most commonly arises from the non-beta islet cells of the pancreas or occasionally from neural crest tissues Excessive circulating VIP binds to intestinal epithelial receptors, activating adenylate cyclase to stimulate massive mucosal secretion of water and electrolytes while inhib...

Excessive circulating VIP binds to intestinal epithelial receptors, activating adenylate cyclase to stimulate massive mucosal secretion of water and electrolytes while inhibiting gastric acid output and intestinal absorption