Disseminated candidiasis

Disseminated candidiasis is a severe, life-threatening form of invasive candidiasis characterized by the hematogenous spread of *Candida* species—most commonly *Candida albicans* and other non-*albicans* species—to multiple sterile body tissues and deep organs Pathophysiologically, yeasts translocate into the vascular system following the disruption of mucosal or cutaneous barriers, subsequently seeding distant sites such as the eyes (endophthalmitis), kidneys, liver, spleen (hepatosplenic candi...

Disseminated candidiasis is a severe, life-threatening form of invasive candidiasis characterized by the hematogenous spread of *Candida* species—most commonly *Candida albicans* and other non-*albicans* species—to multiple sterile body tissues and deep organs

Pathophysiologically, yeasts translocate into the vascular system following the disruption of mucosal or cutaneous barriers, subsequently seeding distant sites such as the eyes (endophthalmitis), kidneys, liver, spleen (hepatosplenic candidiasis), bones, and central nervous system It predominantly affects hospitalized, critically ill, and immunocompromised populations, particularly patients with prolonged neutropenia, hematologic malignancies, central venous catheters, recent major surgery, or e...

Pathophysiologically, yeasts translocate into the vascular system following the disruption of mucosal or cutaneous barriers, subsequently seeding distant sites such as the eyes (endophthalmitis), kidneys, liver, spleen (hepatosplenic candidiasis), bones, and central nervous system Clinical manifestations typically include persistent fever refractory to antibacterial therapy, multiorgan dysfunction, septic shock, and focal findings reflecting specific seeded visceral or cutaneous sites

Pathophysiologically, yeasts translocate into the vascular system following the disruption of mucosal or cutaneous barriers, subsequently seeding distant sites such as the eyes (endophthalmitis), kidneys, liver, spleen (hepatosplenic candidiasis), bones, and central nervous system

Clinical manifestations typically include persistent fever refractory to antibacterial therapy, multiorgan dysfunction, septic shock, and focal findings reflecting specific seeded visceral or cutaneous sites