Disseminated intravascular coagulation

Disseminated intravascular coagulation is a complex, acquired hematologic syndrome characterized by systemic, uncontrolled activation of the coagulation cascade

Disseminated intravascular coagulation is a complex, acquired hematologic syndrome characterized by systemic, uncontrolled activation of the coagulation cascade

It typically occurs secondary to severe underlying conditions such as sepsis, trauma, malignancy, or acute obstetric complications As the condition progresses, the ongoing consumption of platelets and clotting factors, often compounded by secondary fibrinolysis, results in a paradoxical, life-threatening hemorrhagic state

It typically occurs secondary to severe underlying conditions such as sepsis, trauma, malignancy, or acute obstetric complications As the condition progresses, the ongoing consumption of platelets and clotting factors, often compounded by secondary fibrinolysis, results in a paradoxical, life-threatening hemorrhagic state

Pathophysiologically, widespread intravascular fibrin deposition produces microvascular thrombosis, tissue ischemia, and subsequent multiorgan dysfunction

Pathophysiologically, widespread intravascular fibrin deposition produces microvascular thrombosis, tissue ischemia, and subsequent multiorgan dysfunction

As the condition progresses, the ongoing consumption of platelets and clotting factors, often compounded by secondary fibrinolysis, results in a paradoxical, life-threatening hemorrhagic state