Disseminated tuberculosis

Disseminated tuberculosis is a severe, life-threatening form of active tuberculosis characterized by the hematogenous or lymphohematogenous spread of Mycobacterium tuberculosis from an initial pulmonary or extrapulmonary focus to two or more noncontiguous organs or tissues

Disseminated tuberculosis is a severe, life-threatening form of active tuberculosis characterized by the hematogenous or lymphohematogenous spread of Mycobacterium tuberculosis from an initial pulmonary or extrapulmonary focus to two or more noncontiguous organs or tissues It disproportionately impacts immunocompromised individuals, particularly people living with HIV, as well as infants, older adults, and patients receiving immunosuppressive therapies Clinically, it often presents with prolonge...

It disproportionately impacts immunocompromised individuals, particularly people living with HIV, as well as infants, older adults, and patients receiving immunosuppressive therapies

Pathophysiologically, widespread bacillary dissemination leads to multiorgan involvement, frequently affecting the liver, spleen, bone marrow, central nervous system, and lymph nodes

Pathophysiologically, widespread bacillary dissemination leads to multiorgan involvement, frequently affecting the liver, spleen, bone marrow, central nervous system, and lymph nodes Clinically, it often presents with prolonged fever, weight loss, night sweats, cytopenias, and hepatosplenomegaly, and it may manifest radiographically as diffuse miliary micronodules across multiple organ systems