PEMETREXED DISODIUM
FOLATE ANTAGONISTS·MALIGNANT MESOTHELIOMA OF PLEURA·+2
SANDOZ
Indication
EGFR negative, ALK negative, non-small cell lung cancer
Epidermal growth factor receptor (EGFR)-negative, anaplastic lymphoma kinase (ALK)-negative non-small cell lung cancer denotes a molecular subset of non-small cell lung carcinoma—primarily adenocarcinoma or large cell carcinoma of the respiratory tract—whose neoplastic cells lack sensitizing mutations in the *EGFR* gene and rearrangements involving the *ALK* gene. Read more about EGFR negative, ALK negative, non-small cell lung cancer
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Drugs that treat it
Common EGFR negative, ALK negative, non-small cell lung cancer therapies.
PEMETREXED DISODIUM
FOLATE ANTAGONISTS·MALIGNANT MESOTHELIOMA OF PLEURA·+2
Hospira
PEMETREXED DISODIUM
FOLATE ANTAGONISTS·MALIGNANT MESOTHELIOMA OF PLEURA·+2
Hospira
PEMFEXY (pemetrexed)
FOLATE ANTAGONISTS·MALIGNANT MESOTHELIOMA OF PLEURA·+2
ACACIA PHARMA
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Coming soonRelated conditions & guidelines
Coming soonEpidermal growth factor receptor (EGFR)-negative, anaplastic lymphoma kinase (ALK)-negative non-small cell lung cancer denotes a molecular subset of non-small cell lung carcinoma—primarily adenocarcinoma or large cell carcinoma of the respiratory tract—whose neoplastic cells lack sensitizing mutations in the *EGFR* gene and rearrangements involving the *ALK* gene.
Affecting adult patients with primary pulmonary malignancies, this clinical state is pathologically defined by the absence of these two primary oncogenic driver alterations that typically confer sensitivity to targeted receptor tyrosine kinase inhibitors.
Consequently, tumors exhibiting this wild-type biomarker profile lack dependence on EGFR or ALK signaling cascades, distinguishing them biologically from oncogene-addicted lung cancers and determining eligibility for alternative standard systemic regimens, such as immune checkpoint inhibitors and cytotoxic chemotherapy combinations.
- nih.gov
Epidermal growth factor receptor (EGFR)-negative, anaplastic lymphoma kinase (ALK)-negative non-small cell lung cancer denotes a molecular subset of non-small cell lung carcinoma—primarily adenocarcinoma or large cell carcinoma of the respiratory tract—whose neoplastic cells lack sensitizing mutations in the *EGFR* gene and rearrangements involving the *ALK* gene Affecting adult patients with primary pulmonary malignancies, this clinical state is pathologically defined by the absence of these tw...
- lungevity.org
Epidermal growth factor receptor (EGFR)-negative, anaplastic lymphoma kinase (ALK)-negative non-small cell lung cancer denotes a molecular subset of non-small cell lung carcinoma—primarily adenocarcinoma or large cell carcinoma of the respiratory tract—whose neoplastic cells lack sensitizing mutations in the *EGFR* gene and rearrangements involving the *ALK* gene
- go2.org
Affecting adult patients with primary pulmonary malignancies, this clinical state is pathologically defined by the absence of these two primary oncogenic driver alterations that typically confer sensitivity to targeted receptor tyrosine kinase inhibitors
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