Enthesitis-related juvenile idiopathic arthritis

Enthesitis-related juvenile idiopathic arthritis is a chronic inflammatory disorder and specific subtype of juvenile idiopathic arthritis that primarily impacts children and adolescents, most frequently presenting in older boys It predominantly targets the musculoskeletal system, characterized by the co-occurrence of synovitis—typically presenting as asymmetric arthritis of the lower extremity joints—and enthesitis, which is localized inflammation and tenderness where tendons, ligaments, or join...

Enthesitis-related juvenile idiopathic arthritis is a chronic inflammatory disorder and specific subtype of juvenile idiopathic arthritis that primarily impacts children and adolescents, most frequently presenting in older boys It predominantly targets the musculoskeletal system, characterized by the co-occurrence of synovitis—typically presenting as asymmetric arthritis of the lower extremity joints—and enthesitis, which is localized inflammation and tenderness where tendons, ligaments, or join...

It predominantly targets the musculoskeletal system, characterized by the co-occurrence of synovitis—typically presenting as asymmetric arthritis of the lower extremity joints—and enthesitis, which is localized inflammation and tenderness where tendons, ligaments, or joint capsules insert into bone Pathophysiologically categorized under the juvenile spondyloarthritis spectrum, it is strongly associated with the HLA-B27 genetic marker and frequently carries potential progression to axial involvem...

Pathophysiologically categorized under the juvenile spondyloarthritis spectrum, it is strongly associated with the HLA-B27 genetic marker and frequently carries potential progression to axial involvement, including sacroiliitis and spinal inflammation, as well as extra-articular manifestations such as acute anterior uveitis