Erythema multiforme

Erythema multiforme is an acute, immune-mediated hypersensitivity reaction primarily involving the skin and mucous membranes, most frequently occurring in older children and young adults It is predominantly triggered by infections, particularly herpes simplex virus and *Mycoplasma pneumoniae*, though medications can also provoke the disorder The condition is generally self-limiting and categorized into erythema multiforme minor, which involves minimal or no mucosal lesions, and erythema multifor...

Erythema multiforme is an acute, immune-mediated hypersensitivity reaction primarily involving the skin and mucous membranes, most frequently occurring in older children and young adults Pathophysiologically driven by a cell-mediated cytotoxic immune response against host keratinocytes, it classically presents with symmetric, acrally distributed "target" or "iris" lesions exhibiting concentric rings of erythema, edema, and central epidermal necrosis or blistering

It is predominantly triggered by infections, particularly herpes simplex virus and *Mycoplasma pneumoniae*, though medications can also provoke the disorder

Pathophysiologically driven by a cell-mediated cytotoxic immune response against host keratinocytes, it classically presents with symmetric, acrally distributed "target" or "iris" lesions exhibiting concentric rings of erythema, edema, and central epidermal necrosis or blistering

Pathophysiologically driven by a cell-mediated cytotoxic immune response against host keratinocytes, it classically presents with symmetric, acrally distributed "target" or "iris" lesions exhibiting concentric rings of erythema, edema, and central epidermal necrosis or blistering

The condition is generally self-limiting and categorized into erythema multiforme minor, which involves minimal or no mucosal lesions, and erythema multiforme major, characterized by severe mucosal erosions and potential systemic symptoms