Familial Mediterranean fever

Familial Mediterranean fever is an inherited autoinflammatory disorder caused by pathogenic variants in the *MEFV* gene, which encodes the pyrin protein involved in innate immune regulation The condition is characterized by recurrent, self-limiting episodes of fever accompanied by painful serositis involving the peritoneum, pleura, synovium, or skin

Familial Mediterranean fever is an inherited autoinflammatory disorder caused by pathogenic variants in the *MEFV* gene, which encodes the pyrin protein involved in innate immune regulation It primarily affects individuals of Mediterranean and Middle Eastern ancestry, with symptom onset typically occurring in childhood or young adulthood Without proper disease control, persistent systemic inflammation can lead to the accumulation of serum amyloid A protein, causing secondary renal amyloidosis an...

It primarily affects individuals of Mediterranean and Middle Eastern ancestry, with symptom onset typically occurring in childhood or young adulthood The condition is characterized by recurrent, self-limiting episodes of fever accompanied by painful serositis involving the peritoneum, pleura, synovium, or skin

The condition is characterized by recurrent, self-limiting episodes of fever accompanied by painful serositis involving the peritoneum, pleura, synovium, or skin

Without proper disease control, persistent systemic inflammation can lead to the accumulation of serum amyloid A protein, causing secondary renal amyloidosis and progressive kidney failure