Fatigue

Fatigue is a pervasive symptom characterized by a subjective feeling of weariness, profound exhaustion, and a diminished capacity for physical or mental activity that is typically disproportionate to recent exertion and not reliably relieved by rest Clinically, it manifests as persistent lack of energy, cognitive sluggishness, and reduced functional endurance, differentiating it from simple somnolence or localized muscle weakness

Fatigue is a pervasive symptom characterized by a subjective feeling of weariness, profound exhaustion, and a diminished capacity for physical or mental activity that is typically disproportionate to recent exertion and not reliably relieved by rest It affects diverse patient populations across all age groups and can arise from dysfunctions in central nervous, endocrine, metabolic, neuromuscular, or immune systems

Fatigue is a pervasive symptom characterized by a subjective feeling of weariness, profound exhaustion, and a diminished capacity for physical or mental activity that is typically disproportionate to recent exertion and not reliably relieved by rest

It affects diverse patient populations across all age groups and can arise from dysfunctions in central nervous, endocrine, metabolic, neuromuscular, or immune systems

Pathophysiologically, fatigue involves complex mechanisms including systemic neuroinflammation, disrupted neurotransmission, impaired cellular energy metabolism, and altered hypothalamic-pituitary-adrenal axis regulation

Pathophysiologically, fatigue involves complex mechanisms including systemic neuroinflammation, disrupted neurotransmission, impaired cellular energy metabolism, and altered hypothalamic-pituitary-adrenal axis regulation

Clinically, it manifests as persistent lack of energy, cognitive sluggishness, and reduced functional endurance, differentiating it from simple somnolence or localized muscle weakness