Folate deficiency

Folate deficiency is a nutritional and metabolic disorder characterized by insufficient levels of folate (vitamin B9) to support normal cellular function It primarily disrupts hematopoiesis and rapidly proliferating tissues, resulting from inadequate dietary intake, malabsorption disorders, elevated physiologic demands such as pregnancy, or interfering medications Clinically, affected individuals may experience fatigue, weakness, glossitis, elevated serum homocysteine levels, neuropsychiatric sy...

Folate deficiency is a nutritional and metabolic disorder characterized by insufficient levels of folate (vitamin B9) to support normal cellular function Pathophysiologically, depleted folate stores impair one-carbon metabolism and DNA synthesis, which classically manifests as macrocytic megaloblastic anemia marked by hypersegmented neutrophils Clinically, affected individuals may experience fatigue, weakness, glossitis, elevated serum homocysteine levels, neuropsychiatric symptoms, and an incre...

Pathophysiologically, depleted folate stores impair one-carbon metabolism and DNA synthesis, which classically manifests as macrocytic megaloblastic anemia marked by hypersegmented neutrophils

Pathophysiologically, depleted folate stores impair one-carbon metabolism and DNA synthesis, which classically manifests as macrocytic megaloblastic anemia marked by hypersegmented neutrophils