Gastric hypersecretion with systemic mastocytosis

Gastric hypersecretion with systemic mastocytosis is a gastrointestinal complication of a rare hematologic neoplasm marked by the abnormal accumulation and activation of clonal mast cells within extracutaneous tissues

Gastric hypersecretion with systemic mastocytosis is a gastrointestinal complication of a rare hematologic neoplasm marked by the abnormal accumulation and activation of clonal mast cells within extracutaneous tissues This hypersecretory state occurs when systemic degranulation of mast cells releases excessive circulating histamine, which binds to histamine H2 receptors on gastric parietal cells to overstimulate hydrochloric acid production Clinically, affected individuals present with marked in...

This hypersecretory state occurs when systemic degranulation of mast cells releases excessive circulating histamine, which binds to histamine H2 receptors on gastric parietal cells to overstimulate hydrochloric acid production

This hypersecretory state occurs when systemic degranulation of mast cells releases excessive circulating histamine, which binds to histamine H2 receptors on gastric parietal cells to overstimulate hydrochloric acid production Clinically, affected individuals present with marked increases in basal acid output that predispose them to refractory peptic ulcer disease, erosive gastritis, duodenitis, acid-induced diarrhea, and upper gastrointestinal bleeding

Clinically, affected individuals present with marked increases in basal acid output that predispose them to refractory peptic ulcer disease, erosive gastritis, duodenitis, acid-induced diarrhea, and upper gastrointestinal bleeding