Gastroesophageal reflux disease

Gastroesophageal reflux disease is a chronic gastrointestinal disorder characterized by the retrograde flow of gastric contents into the esophagus and upper aerodigestive tract, producing bothersome symptoms or mucosal injury

Gastroesophageal reflux disease is a chronic gastrointestinal disorder characterized by the retrograde flow of gastric contents into the esophagus and upper aerodigestive tract, producing bothersome symptoms or mucosal injury Clinically, it typically presents with heartburn and acid regurgitation, though extraesophageal manifestations such as chronic cough, laryngitis, or chest pain may also occur Prolonged exposure of esophageal tissue to noxious gastric acid and pepsin can lead to complication...

It affects pediatric and adult populations globally and arises primarily from dysfunction of the antireflux barrier, such as transient lower esophageal sphincter relaxations, hypotension of the sphincter, or anatomical disruption from a hiatal hernia

It affects pediatric and adult populations globally and arises primarily from dysfunction of the antireflux barrier, such as transient lower esophageal sphincter relaxations, hypotension of the sphincter, or anatomical disruption from a hiatal hernia Prolonged exposure of esophageal tissue to noxious gastric acid and pepsin can lead to complications including erosive esophagitis, peptic strictures, and Barrett esophagus

It affects pediatric and adult populations globally and arises primarily from dysfunction of the antireflux barrier, such as transient lower esophageal sphincter relaxations, hypotension of the sphincter, or anatomical disruption from a hiatal hernia

Clinically, it typically presents with heartburn and acid regurgitation, though extraesophageal manifestations such as chronic cough, laryngitis, or chest pain may also occur Prolonged exposure of esophageal tissue to noxious gastric acid and pepsin can lead to complications including erosive esophagitis, peptic strictures, and Barrett esophagus