Gastrointestinal stromal tumor

A gastrointestinal stromal tumor is a rare mesenchymal neoplasm of the digestive tract that originates from the interstitial cells of Cajal or their precursors, which function as pacemaker cells regulating gastrointestinal motility Although it can develop anywhere along the alimentary canal, it most commonly arises in the stomach and small intestine, predominantly affecting older adults Behavior ranges from indolent, small nodules to aggressive, highly metastatic sarcomas typically spreading to ...

A gastrointestinal stromal tumor is a rare mesenchymal neoplasm of the digestive tract that originates from the interstitial cells of Cajal or their precursors, which function as pacemaker cells regulating gastrointestinal motility Pathophysiologically, most cases are characterized by mutually exclusive gain-of-function mutations in the *KIT* or *PDGFRA* receptor tyrosine kinase genes, with a small subset driven by succinate dehydrogenase deficiency or other alterations

Pathophysiologically, most cases are characterized by mutually exclusive gain-of-function mutations in the *KIT* or *PDGFRA* receptor tyrosine kinase genes, with a small subset driven by succinate dehydrogenase deficiency or other alterations

Behavior ranges from indolent, small nodules to aggressive, highly metastatic sarcomas typically spreading to the liver and peritoneum